FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members play important roles in embryogenesis, angiogenesis, and wound repair. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. FGF12 plays an intracellular role in the inhibition of radiation-induced apoptosis. FGF12 is expressed abundantly in developing and adult nervous systems; therefore, FGF12 was thought to be related to nervous system development and function.
Antibodies
Application
Western Blot
Application Note
For research purposes only. Not for use in humans.
Dilution
1:500 - 1:1000
Host
Rabbit Polyclonal
Immunogen
Recombinant protein corresponding to Mouse FGF12
Isotype
IgG
Molecular Weight
27 kDa
Positive Tissue
brain, cortex
Purity
Affinity purification
Species
Mouse, Rat
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
