Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulphate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signalling pathways, does not activate angiogenesis and inhibits tumour growth. Binding to NRP1 receptor initiates a signalling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Antibodies
Application
Immunohistochemistry, Immunofluorescence
Application Note
For research purposes only. Not for use in humans.
Host
Mouse
Immunogen
Synthesized peptide derived from human Vascular Endothelial Growth Factor
