SMAD2, also named as MADH2 and MADR2, belongs to the dwarfin/SMAD family, contains 1 MH1 (MAD homology 1) domain and 1 MH2 (MAD homology 2) domain. SMAD2 is a receptor-regulated SMAD(R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. This protein may act as a tumour suppressor in colorectal carcinoma. It is phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, It is phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases, and then able to interact with SMURF2, recruiting other proteins, such as SNON, for degradation.
Antibodies
Application
Western Blot
Application Note
For research purposes only. Not for use in humans.
Host
Rabbit Polyclonal
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Smad2 + Smad3
Isotype
IgG
Molecular Weight
52 kDa
Positive Tissue
HeLa, HepG2, NIH/3T3, C2C12, HEK293, PC-12
Purity
Affinity purification
Species
Human, Mouse, Rat
Synonyms
MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD2, MADH2, MADR2
