PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumour cell growth.
Antibodies
Application
Immunohistochemistry, Immunofluorescence
Application Note
For research purposes only. Not for use in humans.
Dilution
1:600 - 1:3000
Host
Rabbit Polyclonal
Immunogen
Recombinant protein corresponding to Mouse PCGF1
Isotype
IgG
Positive Tissue
Testis
Purity
Affinity purification
Species
Mouse, Rat
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Subcellular Location
Nucleus
Synonyms
Nervous system Polycomb-1, NSPc1, RING finger protein 68, Pcgf1, Nspc1, Rnf68
