IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
Antibodies
Application
Immunohistochemistry, Immunofluorescence
Application Note
For research purposes only. Not for use in humans.
Dilution
1:500 - 1:1500
Host
Rabbit Polyclonal
Immunogen
Recombinant protein corresponding to Mouse IL-34
Isotype
IgG
Positive Tissue
colon, heart
Purity
Affinity purification
Species
Mouse, Rat
Subcellular Location
Secreted
Synonyms
IL-34, Chromosome 16 open reading frame 77 , C16orf77, FPT025
