Recombinant Human Thrombospondin Type - 1 Domain - Containing Protein 7A, THSD7A

THSD7A was first identified as an endothelial protein that is expressed in the vascular system of the placenta (1). It is expressed by cells of endothelial and neuronal lineage. The soluble form of THSD7A promotes endothelial cell migration and filopodia formation during a giogenesis via a FAK-dependent mechanism (2).This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. THSD7A is expressed on podocytes and is responsible for 2 - 5%of patients with idiopathic membranous nephropathy (3, 4, 5)