This protein is a dimeric enzyme that is expressed on the exterior face of the plasma
membrane (1, 2). CD73 acts by hydrolysing nucleotide monophosphates, thereby releasing
inorganic phosphate and the corresponding nucleoside. Exhibits AMP-, NAD-, and NMNnucleosidase activities (3). CD73, originally defined as a lymphocyte differentiation antigen,
is thought to function as a co-signalling molecule on T lymphocytes and as an adhesion
molecule that is important for lymphocyte binding to endothelium (4). CD73 is involved in
the control of a variety of physiological responses including epithelial ion and fluid
transport, ischemic preconditioning, tissue injury, platelet function, hypoxia and vascular
leak (5).
CD 73 is a potential target in immuno-oncology (6, 7).
Product is shipped either on dry or wet ice or frozen gel packs. Upon receipt, store at -20°C
to -70°C.
Antibodies
Amino Acids
27-549
Application Note
For research purposes only. Not for use in humans.
Endotoxins
Less than 0.1 ng/µg (1 IEU/µg), as measured by LAL method.
Formulations
PBS 20% Glycerol
Grade & Purity
>95% as estimated by SDS-PAGE stained with Instant Blue Stain
(Expedeon)
