It is a single-pass transmembrane protein composed of three extracellular Ig-like domains,
a transmembrane region, and a tyrosine kinase domain (1, 2). Tyrosine-protein kinase that
acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the
regulation of cell proliferation, differentiation, migration and apoptosis, and in the
regulation of embryonic development (3, 4, 5, 6). Required for normal embryonic
patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis
and skin development. Plays an essential role in the regulation of osteoblast differentiation,
proliferation and apoptosis, and is required for normal skeleton development. Promotes cell
proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in
differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4 (7). Ligand binding leads
to the activation of several signalling cascades. Activation of PLCG1 leads to the production
of the cellular signalling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and
mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signalling
pathway, as well as of the AKT1 signalling pathway (8). FGFR2 signalling is down-regulated
by ubiquitination, internalization and degradation. Mutations that lead to constitutive
kinase activation or impair normal FGFR2 maturation, internalization and degradation lead
to aberrant signalling (9). Over-expressed FGFR2 promotes activation of STAT1.
Product is shipped either on dry or wet ice. Upon receipt, store at -20°C to -70°C.
Antibodies
Amino Acids
22-378
Application Note
For research purposes only. Not for use in humans.
Endotoxins
Less than 0.1 ng/µg (1 IEU/µg), as measured by LAL method.
Formulations
PBS 20% Glycerol
Grade & Purity
>95% as estimated by SDS-PAGE stained with Instant Blue Stain
(Expedeon)
