Carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood
volume, systemic vascular resistance, and thus cardiovascular homeostasis (1). Converts
angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in
cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator
and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II
(2,3). Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human
coronavirus NL63/HCoV-NL63 (4-9).
Product is shipped on dry or wet ice or frozen gel packs. Upon receipt, store at -20°C to -70°C.
Antibodies
Amino Acids
19-740
Application Note
For research purposes only. Not for use in humans
Endotoxins
Less than 0.1 ng/µg (1 IEU/µg), as measured by LAL method.
Formulations
PBS 20% Glycerol
Grade & Purity
>90% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).
