CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumour growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in haematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes.
Antibodies
Application
Western Blot, Immunohistochemistry, Immunofluorescence
Application Note
For research purposes only. Not for use in humans.
Dilution
[WB: 1:100 - 1:300]; [IHC,IF: 1:150 - 1: 600]
Host
Rabbit
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse CD44
