Most of autosomal dominant familial AD can be attributed to mutations in one of three genes: those encoding amyloid precursor protein (APP) and presenilins 1 and 2 Most mutations in the APP and presenilin genes increase the production of a small protein called Aβ42, which is the main component of senile plaques. Some of the mutations merely alter the ratio between Aβ42 and the other major forms—particularly Aβ40—without increasing Aβ42 levels.
Antibodies
Application
Immunohistochemistry
Application Note
For research purposes only. Not for use in humans.
Dilution
1:400 - 1:800
Host
Rabbit Polyclonal
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Aβ40
Isotype
IgG
Positive Tissue
AD brain
Purity
Affinity purification
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
